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Invitrogen
SLC19A1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-55190
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SLC19A1. Recombinant protein control fragment (Product #RP-91233).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: AQALSVQDKG LGGLQPAQSP PLSPEDSLGA VGPASLEQRQ SDPYLAQAPA PQAAEFLSPV TTPSPCTLCS AQASGPEAAD ETCPQLAVHP PGVSKLGLQC LPSDGVQNV
Highest antigen sequence identity to the following orthologs: Mouse - 28%, Rat - 27%.
Target Information
Transport of folate compounds into mammalian cells can occur via receptor-mediated or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyclic dinucleotide:anion antiporter SLC19A1; folate transporter 1; folate:anion antiporter SLC19A1; intestinal folate carrier 1; placental folate transporter; reduced folate carrier 1; reduced folate carrier protein; reduced folate transporter 1; solute carrier family 19 (folate transporter), member 1; unnamed protein product
Gene Aliases: CHMD; FOLT; hRFC; hSLC19A1; IFC-1; IFC1; IMD114; MEGAF; REFC; RFC; RFC1; RFT-1
UniProt ID: (Human) P41440
Entrez Gene ID: (Human) 6573
protein binding
folic acid binding
folic acid transporter activity
reduced folate carrier activity
antiporter activity
methotrexate transporter activity
transmembrane transporter activity
xenobiotic transporter activity
cyclic-GMP-AMP binding
vitamin transmembrane transporter activity
cyclic-GMP-AMP transmembrane transporter activity
drug transmembrane transport
female pregnancy
response to xenobiotic stimulus
response to toxic substance
folic acid transport
folic acid metabolic process
vitamin transport
methotrexate transport
transmembrane transport
anion transmembrane transport
reduced folate transmembrane transport
cyclic-GMP-AMP transmembrane import across plasma membrane
positive regulation of cGAS/STING signaling pathway
transport across blood-brain barrier
folic acid import into cell
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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