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Invitrogen
TC2N Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-55651
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TC2N. Recombinant protein control fragment (Product #RP-88889).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.10 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: IKSCCGGCFY GETEKHNFSV ERDFKAAVPN SQNATISVPP LTSVSVKPQL GCTEDYLLSK LPSDGKEVPF VVPKFKLSYI QPRTQETPSH LEELEGSARA SFGDRKVELS SSSQHGPSYD VYNPFYMYQH ISPDLSRRF
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 78%.
Target Information
The TC2N gene encodes the Tandem C2 domains nuclear protein, which is characterized by the presence of two C2 domains, C2A and C2B, at the C-terminus. These domains are structured as an eight-stranded antiparallel beta-sandwich, initially recognized as a Ca2+ binding module. TC2N's role varies significantly across different types of cancer. It has been identified as an oncogene in lung, gastric, and hepatocellular carcinomas, where its overexpression promotes cell proliferation, migration, and metastasis. Conversely, in breast cancer, TC2N functions as a tumor suppressor, inhibiting distant metastasis and stemness via the PI3K-Akt signaling pathway. These dual roles highlight its complex involvement in tumorigenesis, with its impact being highly context-dependent on the cancer type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C2 calcium-dependent domain containing 1; membrane targeting (tandem) C2 domain containing 1; tandem C2 protein in nucleus; unnamed protein product
Gene Aliases: C14orf47; C2CD1; MTAC2D1; Tac2-N; TAC2N
UniProt ID: (Human) Q8N9U0
Entrez Gene ID: (Human) 123036
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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