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Invitrogen
WFS1 Polyclonal Antibody
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Product Details
PA5-56064
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human WFS1. Recombinant protein control fragment (Product #RP-90661).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KHPCHIKKFD RYKFEITVGM PFSSGADGSR SREEDDVTKD IVLRASSEFK SVLLSLRQGS LIEFSTILEG RLGSKWPVFE LKAISCLNCM AQLSPTRRHV KIEHDW
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.
Target Information
WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas. It is normally up-regulated during insulin secretion, whereas inactivation of the protein can cause ER stress. Chronic ER stress is a major involvement in Wolfram syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: unnamed protein product; Wolfram antibody; Wolfram syndrome 1 (wolframin); Wolfram syndrome 1 (wolframin) isoform WFS1_1; Wolfram syndrome 1 (wolframin) isoform WFS1_2; Wolframin
Gene Aliases: CTRCT41; WFRS; WFS; WFS1; WFSL
UniProt ID: (Human) O76024
Entrez Gene ID: (Human) 7466
negative regulation of transcription from RNA polymerase II promoter
kidney development
renal water homeostasis
ER overload response
visual perception
sensory perception of sound
regulation of gene expression
negative regulation of macromolecule biosynthetic process
negative regulation of translation
endoplasmic reticulum unfolded protein response
pancreas development
positive regulation of protein ubiquitination
endoplasmic reticulum calcium ion homeostasis
response to endoplasmic reticulum stress
intracellular signal transduction
ERAD pathway
olfactory behavior
glucose homeostasis
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of neuron apoptotic process
positive regulation of growth
protein stabilization
neurological system process
positive regulation of protein metabolic process
positive regulation of calcium ion transport
calcium ion homeostasis
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of intracellular signal transduction
negative regulation of response to endoplasmic reticulum stress
negative regulation of ATF6-mediated unfolded protein response
positive regulation of ERAD pathway
negative regulation of type B pancreatic cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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