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Invitrogen
LRGUK Polyclonal Antibody
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Product Details
PA5-56175
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human LRGUK. Recombinant protein control fragment (Product #RP-92765).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SNMGDFLHST DRNYLIKFWA KLSAKKTPAE RDSIHRQHEA ARQALMGRIR PDHTLLFQRG PVPAPLTSGL HYYTTLEELW KSFDLCEDYF KPPFG
Highest antigen sequence identity to the following orthologs: Mouse - 64%, Rat - 61%.
Target Information
The LRGUK (Leucine-Rich Repeat and Guanylate Kinase-Like Domain Containing 1) gene encodes a protein that plays a critical role in male fertility. It is particularly important for the proper function of the manchette, a microtubule-based structure involved in sperm head shaping and tail formation during spermiogenesis. Research has shown that LRGUK1 is part of a multiprotein complex essential for the initiation of sperm tail growth from the centriole/basal body. Mutations or disruptions in the LRGUK1 gene can lead to defective manchette function, resulting in abnormal sperm morphology and infertility. This gene's role in spermatogenesis underscores its importance in reproductive health, with ongoing studies aimed at elucidating its specific interactions and mechanisms within the manchette complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leucine-rich repeat and guanylate kinase domain-containing protein; leucine-rich repeats and guanylate kinase domain containing
Gene Aliases: CFAP246; LRGUK
UniProt ID: (Human) Q96M69
Entrez Gene ID: (Human) 136332
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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