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Invitrogen
ITPKB Polyclonal Antibody
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Product Details
PA5-56425
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ITPKB. Recombinant protein control fragment (Product #RP-94308).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PDKPFLRKAC SPSNIPAVII TDMGTQEDGA LEETQGSPRG NLPLRKLSSS SASSTGFSSS YEDSEEDISS DPE
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 82%.
Target Information
Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) regulates the level of calcium within the cell by releasing calcium from intracellular stores. Ins(1,4,5)P3 is phosphorylated by inositol 1,4,5-trisphosphate 3-kinase (IP3K) to form inositol 1,3,4,5-tetrakisphosphate (Ins(1,4,5)P4), which is is thought to regulate the influx of calcium across the plasma membrane. IP3K exists as three isoforms, IP3KA, B, and C. IP3KA, the most highly characterized isoform, is expressed in rat brain and testis. IP3KB is expressed in various rat tissues such as lung, thymus, testis, brain, and heart. IP3K activity is stimulated in the presence of calmodulin via phosphorylation by cAMP-dependent protein kinase, protein kinase C, or calcium/calmodulin dependent protein kinase II and, subsequently, mediates the inositol phosphate signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Inositol 1,4,5-trisphosphate 3-kinase B; Inositol-trisphosphate 3-kinase B; insP 3-kinase B; IP3 3-kinase B; IP3K B; proliferation-inducing protein 37; unnamed protein product
Gene Aliases: IP3-3KB; IP3K; IP3K-B; IP3KB; ITPKB; PIG37
UniProt ID: (Human) P27987
Entrez Gene ID: (Human) 3707
MAPK cascade
myeloid cell homeostasis
signal transduction
cell surface receptor signaling pathway
T cell differentiation
inositol trisphosphate metabolic process
inositol phosphate biosynthetic process
negative regulation of neutrophil apoptotic process
common myeloid progenitor cell proliferation
positive thymic T cell selection
thymic T cell selection
negative regulation of myeloid cell differentiation
positive regulation of Ras protein signal transduction
positive regulation of alpha-beta T cell differentiation
phosphatidylinositol phosphorylation
cellular response to calcium ion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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