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Invitrogen
SH3YL1 Polyclonal Antibody
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Product Details
PA5-56593
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SH3YL1. Recombinant protein control fragment (Product #RP-95959).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FTYCKSRGLF AGVSLEGSCL IERKETNRKF YCQDIRAYDI LFGDTPRPAQ AEDLYEILDS FTEKYENEG
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.
Target Information
The SH3YL1 gene encodes a protein that contains an SH3 domain and is involved in various signaling pathways. It is particularly significant in the context of androgen receptor (AR) signaling, where it acts as a coregulator for AR target genes. Studies have shown that SH3YL1 is essential for the transcriptional activation of genes modulated by the AR, and its dysregulation is associated with aggressive prostate cancer. Additionally, elevated plasma levels of SH3YL1 have been identified as a biomarker for diabetic nephropathy, indicating its broader role in human health and disease. SH3YL1 protein expression is particularly noted in the kidneys of diabetic patients, suggesting its involvement in the development of diabetic complications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: SH3 domain containing, Ysc84-like 1; SH3 domain-containing YSC84-like protein 1
Gene Aliases: RAY; SH3YL1
UniProt ID: (Human) Q96HL8
Entrez Gene ID: (Human) 26751
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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