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Invitrogen
PPM1F Polyclonal Antibody
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Product Details
PA5-56610
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PPM1F. Recombinant protein control fragment (Product #RP-95347).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VVPHQEVVGL VQSHLTRQQG SGLRVAEELV AAARERGSHD NITVMVVFLR DPQELLEGGN QGEGDPQAEG RRQDLPSSLP EPETQ
Highest antigen sequence identity to the following orthologs: Mouse - 67%, Rat - 68%.
Target Information
PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ca(2+)/calmodulin-dependent protein kinase phosphatase; CaM-kinase phosphatase; hFem-2; Partner of PIX 2; PP2C phosphatase; Protein fem-2 homolog; Protein phosphatase 1F; protein phosphatase 1F (PP2C domain containing); protein phosphatase, Mg2+/Mn2+ dependent, 1F
Gene Aliases: CAMKP; CaMKPase; FEM-2; hFEM-2; KIAA0015; POPX2; PPM1F
UniProt ID: (Human) P49593
Entrez Gene ID: (Human) 9647
negative regulation of protein kinase activity
positive regulation of gene expression
positive regulation of epithelial cell migration
positive regulation of cell-substrate adhesion
histone dephosphorylation
negative regulation of peptidyl-serine phosphorylation
cellular response to drug
peptidyl-threonine dephosphorylation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of protein kinase activity by regulation of protein phosphorylation
negative regulation of transcription, DNA-templated
positive regulation of growth
positive regulation of chemotaxis
positive regulation of stress fiber assembly
positive regulation of focal adhesion assembly
intrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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