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Invitrogen
SKIP Polyclonal Antibody
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Product Details
PA5-56622
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SKIP. Recombinant protein control fragment (Product #RP-89613).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LVFAKYQHLP YIQILSTKST PTGLFGYWGN KGGVNICLKL YGYYVSIINC HLPPHISNNY QRLEHFDRIL EMQNCEGRDI PNILDHDLII WFGDMNFRIE DFGLHFVRES IKNRCYGGLW EKDQLSI
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 80%.
Target Information
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Inositol polyphosphate 5-phosphatase K; phosphatidylinositol (4,5)bisphosphate 5-phosphatase homolog; has similarity to motifs conserved in phosphatidylinositol (4,5)bisphosphate 5-phosphatases, Swiss-Prot Accession Number Q01968, and the product of GenBank Accession Number M74161; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase; Skeletal muscle and kidney-enriched inositol phosphatase; unnamed protein product
Gene Aliases: INPP5K; MDCCAID; PPS; SKIP
UniProt ID: (Human) Q9BT40
Entrez Gene ID: (Human) 51763
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
inositol-polyphosphate 5-phosphatase activity
vasopressin receptor activity
protein binding
inositol bisphosphate phosphatase activity
hydrolase activity
phosphatase activity
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
phosphatidylinositol trisphosphate phosphatase activity
phosphatidylinositol phosphate 5-phosphatase activity
lipid phosphatase activity
inositol trisphosphate phosphatase activity
inositol-1,4,5-trisphosphate 5-phosphatase activity
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
in utero embryonic development
regulation of glycogen biosynthetic process
lipid metabolic process
phospholipid metabolic process
phosphatidylinositol biosynthetic process
G-protein coupled receptor signaling pathway
negative regulation of glucose transport
actin cytoskeleton organization
response to insulin
cellular response to insulin stimulus
cellular response to hormone stimulus
negative regulation of dephosphorylation
positive regulation of urine volume
glucose homeostasis
negative regulation by host of viral transcription
negative regulation of glycogen biosynthetic process
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
glycerolipid metabolic process
negative regulation of insulin receptor signaling pathway
phosphatidylinositol dephosphorylation
regulation of transport
negative regulation of stress fiber assembly
negative regulation of protein kinase B signaling
negative regulation of calcium ion transport
cellular response to cAMP
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
protein localization to plasma membrane
negative regulation of protein targeting to membrane
ruffle assembly
cellular response to oxygen-containing compound
negative regulation of RNA biosynthetic process
positive regulation of renal water transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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