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Invitrogen
Kir6.1 (KCNJ8) Polyclonal Antibody
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Product Details
PA5-56628
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human KCNJ8. Recombinant protein control fragment (Product #RP-101008).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KRSPLYDISA TDLANQDLEV IVILEGVVET TGITTQARTS YIAEEIQWGH RFVSIVTEEE GVYSVDYSKF GNTVKVAAPR CSARELDEKP SILIQTLQKS ELSHQNSLRK RNSMRRNNSM RRNNSIRRNN SSLMVPKVQF MTPEGNQNT
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 97%.
Target Information
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. KCNJ8 is an integral membrane protein and inward-rectifier type potassium channel. KCNJ8, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP-sensitive inward rectifier potassium channel 8; Inward rectifier K(+) channel Kir6.1; inwardly rectifying potassium channel KIR6.1; Potassium channel, inwardly rectifying subfamily J member 8; potassium voltage-gated channel subfamily J member 8; uKATP-1; unnamed protein product
Gene Aliases: KCNJ8; KIR6.1; uKATP-1
UniProt ID: (Human) Q15842
Entrez Gene ID: (Human) 3764
inward rectifier potassium channel activity
protein binding
ATP binding
ATP-activated inward rectifier potassium channel activity
sulfonylurea receptor binding
cation-transporting ATPase activity
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
action potential
blood vessel development
response to hypoxia
microglial cell activation
kidney development
vasculature development
regulation of heart rate
adaptive immune response
response to ischemia
heart morphogenesis
ventricular cardiac muscle tissue development
ion transport
potassium ion transport
apoptotic process
response to stress
inflammatory response
heart development
regulation of blood pressure
cell proliferation
determination of adult lifespan
protein secretion
response to xenobiotic stimulus
gene expression
fatty acid transport
transmission of nerve impulse
establishment of cell polarity
response to lipopolysaccharide
response to insulin
response to ATP
response to cytokine
ion transmembrane transport
regulation of ion transmembrane transport
response to endoplasmic reticulum stress
p38MAPK cascade
vasodilation
response to exogenous dsRNA
NLRP3 inflammasome complex assembly
fat cell differentiation
fibroblast proliferation
neurological system process
neuromuscular process
synaptic growth at neuromuscular junction
defense response to virus
cardiac pacemaker cell differentiation
atrioventricular node cell differentiation
coronary vasculature development
glutamate secretion, neurotransmission
CAMKK-AMPK signaling cascade
calcium ion transmembrane transport
potassium ion transmembrane transport
circulatory system development
inorganic cation transmembrane transport
membrane repolarization during ventricular cardiac muscle cell action potential
regulation of presynaptic membrane potential
reactive gliosis
transport across blood-brain barrier
response to resveratrol
potassium ion import across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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