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Invitrogen
PKHD1 Polyclonal Antibody
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Product Details
PA5-56682
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PKHD1. Recombinant protein control fragment (Product #RP-94948).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KTTTVNYVRD TLSNPRGWMA LLLDQETYSL QSENLWINRS LQYSATFDNF APGNYLLLVH TDLPPYPDIL LRCGSRVGLS FPFLPSPGQN Q
Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 26%.
Target Information
The protein encoded by this gene is predicted to have a single transmembrane (TM)-spanning domain and multiple copies of an immunoglobulin-like plexin-transcription-factor domain. Alternative splicing results in two transcript variants encoding different isoforms. Other alternatively spliced transcripts have been described, but the full length sequences have not been determined. Several of these transcripts are predicted to encode truncated products which lack the TM and may be secreted. Mutations in this gene cause autosomal recessive polycystic kidney disease, also known as polycystic kidney and hepatic disease-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AI118496; AI182499; Fibrocystin; fibrocystin/polyductin complex; PKHD1, fibrocystin/polyductin; polycystic kidney and hepatic disease 1 (autosomal recessive); Polycystic kidney and hepatic disease 1 protein; Polyductin; TIG multiple domains 1; Tigmin; unnamed protein product
Gene Aliases: ARPKD; FCYT; FPC; PCYT; PKD4; PKHD1; TIGM1
UniProt ID: (Human) P08F94
Entrez Gene ID: (Human) 5314
establishment of mitotic spindle orientation
kidney development
regulation of cell-matrix adhesion
epithelial cell morphogenesis
cellular calcium ion homeostasis
positive regulation of cell proliferation
regulation of centrosome duplication
regulation of cell-cell adhesion
regulation of cell adhesion
regulation of TOR signaling
negative regulation of NF-kappaB transcription factor activity
homeostatic process
negative regulation of apoptotic process
cell-cell junction organization
branching morphogenesis of an epithelial tube
positive regulation of epithelial cell proliferation
establishment of centrosome localization
negative regulation of protein kinase B signaling
cilium morphogenesis
regulation of ERK1 and ERK2 cascade
regulation of establishment of planar polarity
cell-cell adhesion
negative regulation of epithelial cell apoptotic process
regulation of cholangiocyte proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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