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Invitrogen
V-ATPase D Polyclonal Antibody
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FIGURE: 1 / 7
V-ATPase D Antibody (PA5-56767) in IHC
Immunohistochemical staining of V-ATPase D in human kidney, liver, lymph node and testis using V-ATPase D Polyclonal Antibody (Product # PA5-56767) (A) shows similar protein distribution across tissues to an independent V-ATPase D Polyclonal Antibody (B).
Product Details
PA5-56767
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human V-ATPase D. Recombinant protein control fragment (Product #RP-95567).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VNAIEHVIIP RIERTLAYII TELDEREREE FYRLKKIQEK KKILKEKSEK DLEQRRAAGE VLEPANLLAE
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 96%.
Target Information
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATPase, H+ transporting lysosomal (vacuolar proton pump); ATPase, H+ transporting lysosomal, member M; ATPase, H+ transporting, lysosomal (vacuolar proton pump); ATPase, H+ transporting, lysosomal 34kD, V1 subunit D; ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D; ATPase, H+ transporting, V1 subunit D; H(+)-transporting two-sector ATPase, subunit M; lysosomal 34kDa; unnamed protein product; V-ATPase 28 kDa accessory protein; V-ATPase D subunit; V-ATPase subunit D; V-type proton ATPase subunit D; vac; vacuolar ATP synthase subunit D; vacuolar H-ATPase subunit D; vacuolar proton pump D subunit; vacuolar proton pump delta polypeptide; Vacuolar proton pump subunit D; vacuolar proton-ATPase subunit D
Gene Aliases: 1110004P10Rik; ATP6M; ATP6V1D; VATD; VMA8
UniProt ID: (Human) Q9Y5K8, (Mouse) P57746
Entrez Gene ID: (Human) 51382, (Rat) 299159, (Mouse) 73834
ion transport
vacuolar acidification
lysosomal lumen acidification
regulation of macroautophagy
cell projection organization
endosomal lumen acidification
intracellular pH reduction
cilium morphogenesis
protein localization to cilium
Golgi lumen acidification
synaptic vesicle lumen acidification
hydrogen ion transmembrane transport
cilium assembly
transmembrane transport
transport
proton transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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