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Invitrogen
JIP2 Polyclonal Antibody
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Product Details
PA5-57057
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human JIP2. Recombinant protein control fragment (Product #RP-94964).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FSLSTFHSLS PPGCRPPQDI SLEEFDDEDL SEITDDCGLG LSYDSDHCEK DSLSLGRSEQ PHPICSFQDD FQEFEM
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-Jun-amino-terminal kinase-interacting protein 2; homologous to mouse JIP-1; IB 2; IB-2; Islet brain 2; islet-brain 2; Islet-brain-2; JIP 2; JIP-2; JNK MAP kinase scaffold protein 2; JNK MAP kinase scaffold protein JIP2; JNK-interacting protein 2; Mitogen-activated protein kinase 8-interacting protein 2
Gene Aliases: IB-2; IB2; JIP2; MAPK8IP2; PRKM8IPL
UniProt ID: (Human) Q13387
Entrez Gene ID: (Human) 23542
behavioral fear response
signal complex assembly
JNK cascade
mating behavior
regulation of receptor activity
positive regulation of stress-activated MAPK cascade
social behavior
regulation of JNK cascade
nonassociative learning
dendrite morphogenesis
regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
regulation of N-methyl-D-aspartate selective glutamate receptor activity
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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