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Invitrogen
DHX36 Polyclonal Antibody
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Product Details
PA5-57259
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DHX36. Recombinant protein control fragment (Product #RP-96443).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ERREEQIVQL LNSVQAKNDK ESEAQISWFA PEDHGYGTEV STKNTPCSEN KLDIQEKKLI NQEKKMFRIR NRSYIDRDSE YLLQENEPDG T
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 79%.
Target Information
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure. DHX36 (DEAH box protein 36), also known as MLE-like protein 1 and RNA helicase associated with AU-rich element ARE (RHAU), belongs to RNA helicase of the DEAH family and may function in sex development and spermatogenesis. It is expressed in testis and is evolutionary conserved with true orthologs in almost all animal species. DHX36 plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. DHX36 is required for early embryogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Asp-Glu-Ala-His; ATP-dependent DNA/RNA helicase DHX36; ATP-dependent RNA helicase DHX36; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36; DEAD/H box polypeptide 36; DEAH (Asp-Glu-Ala-His) box polypeptide 36; DEAH box protein 36; DEAH-box protein 36; G4 resolvase-1; G4-resolvase-1; G4R1; MLE-like protein 1; probable ATP-dependent RNA helicase DHX36; RNA helicase associated with AU-rich element ARE; RNA helicase associated with AU-rich element protein; unnamed protein product
Gene Aliases: DDX36; DHX36; G4R1; KIAA1488; MLEL1; RHAU
UniProt ID: (Human) Q9H2U1
Entrez Gene ID: (Human) 170506
nucleotide binding
magnesium ion binding
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
G-quadruplex RNA binding
nucleic acid binding
DNA binding
DNA helicase activity
single-stranded DNA binding
RNA binding
RNA helicase activity
double-stranded RNA binding
mRNA 3'-UTR binding
helicase activity
protein binding
ATP binding
DNA-dependent ATPase activity
hydrolase activity
ATPase activity
mRNA 3'-UTR AU-rich region binding
histone deacetylase binding
metal ion binding
mRNA 5'-UTR binding
G-quadruplex DNA binding
telomerase RNA binding
pre-miRNA binding
catalytic activity, acting on a nucleic acid
ossification
immune system process
positive regulation of myeloid dendritic cell cytokine production
regulation of transcription from RNA polymerase III promoter
regulation of translation
spermatogenesis
response to virus
positive regulation of gene expression
negative regulation of translation
cell differentiation
positive regulation of mRNA 3'-end processing
positive regulation of telomere maintenance
positive regulation of interferon-alpha production
cellular response to heat
cellular response to UV
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to exogenous dsRNA
regulation of mRNA stability
innate immune response
positive regulation of translation
positive regulation of transcription from RNA polymerase II promoter
regulation of embryonic development
defense response to virus
positive regulation of cardioblast differentiation
positive regulation of transcription initiation from RNA polymerase II promoter
positive regulation of dendritic spine morphogenesis
3'-UTR-mediated mRNA destabilization
telomerase RNA stabilization
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
positive regulation of hematopoietic progenitor cell differentiation
cellular response to arsenite ion
positive regulation of telomere maintenance via telomere lengthening
positive regulation of intracellular mRNA localization
positive regulation of cytoplasmic translation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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