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Invitrogen
MMRN1 Polyclonal Antibody
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Product Details
PA5-57392
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MMRN1. Recombinant protein control fragment (Product #RP-96663).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RHNLLRNEVQ GRDDALERRI NEYALEMEDG LNKTMTIINN AIDFIQDNYA LKETLSTIKD NSEIHHKCTS DMETILTFIP QFHRLND
Highest antigen sequence identity to the following orthologs: Mouse - 66%, Rat - 63%.
Target Information
Multimerin-1, also known as MMRN1, EMILIN-4 or ECM (endothelial cell multimerin), is a 1,228 amino acid secreted protein that contains one C1q domain, one EMI domain and one EGF-like domain. Synthesized in megakaryocytes and endothelial cells and present in liver, lung and placenta, Multimerin-1 exists as a multimeric structure composed of varying disulfide-linked multimers and functions as a carrier protein for platelet factors (specifically platelet factor V), playing a role in the stabilization and storage of factor V in platelets. In addition, Multimerin-1 acts as a ligand for select Integrins and may participate in extracellular matrix adhesion. Defects in the gene encoding Multimerin-1 that lead to Multimerin-1 deficiency are associated with autosomal dominant bleeding disorders due to platelet factor malfunction. Multiple isoforms of Multimerin-1 exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Elastin microfibril interface located protein 4; Elastin microfibril interfacer 4; EMILIN-4; Endothelial cell multimerin; glycoprotein Ia*; Multimerin-1; p155; unnamed protein product
Gene Aliases: ECM; EMILIN4; GPIA*; MMRN; MMRN1
UniProt ID: (Human) Q13201
Entrez Gene ID: (Human) 22915
cell adhesion
blood coagulation
negative regulation of vascular endothelial growth factor receptor signaling pathway
cell adhesion mediated by integrin
negative regulation of wound healing
negative regulation of cell migration involved in sprouting angiogenesis
positive regulation of platelet aggregation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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