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Invitrogen
PPP2R3A Polyclonal Antibody
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Product Details
PA5-57415
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PPP2R3A. Recombinant protein control fragment (Product #RP-96286).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EQRDPFAVQK DVENDGPEPS DWDRFAAEEY ETLVAEESAQ AQFQEGFEDY ETDEPASPSE FGNKSNKILS ASLPEKCGKL QSVDEE
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 85%.
Target Information
Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B'/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holoenzyme. The product of this gene belongs to the B' family. The B' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B'. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA for thyroid hormone receptor binding site (258bp); PP2A subunit B isoform PR72/PR130; PP2A subunit B isoform R3 isoform; PP2A subunit B isoforms B''-PR72/PR130; PP2A subunit B isoforms B72/B130; PP2A, subunit B, R3 isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B'' (PR 72), alpha isoform and (PR 130), beta isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha; protein phosphatase 2 regulatory subunit B'', alpha; protein phosphatase 2, regulatory subunit B'', alpha; Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B; Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
Gene Aliases: 3222402P14Rik; A730042E07; PPP2R3; PPP2R3A; PR130; PR72
UniProt ID: (Human) B4DNU1
Entrez Gene ID: (Human) 5523, (Mouse) 235542, (Rat) 363122
protein dephosphorylation
regulation of protein phosphatase type 2A activity
somite development
eye photoreceptor cell differentiation
somatic muscle development
positive regulation of protein catabolic process
negative regulation of canonical Wnt signaling pathway
regulation of cell motility involved in somitogenic axis elongation
positive regulation of canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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