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          • Primary Antibodies ›
          • SH3PXD2B Antibodies

          Invitrogen

          SH3PXD2B Polyclonal Antibody

          Advanced Verification
          2 Published Figures
          2 References
          View all (4) SH3PXD2B antibodies

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          Cite SH3PXD2B Polyclonal Antibody

          Additional Information:
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          {{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
          • Antibody Testing Data (6)
          • Published Figures (2)
          • Advanced Verification (2)
          SH3PXD2B Antibody in Immunocytochemistry (ICC/IF)
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          SH3PXD2B Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 10

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          SH3PXD2B Antibody (PA5-57673) in ICC/IF

          Immunofluorescent staining of SH3PXD2B in human cell line U-2 OS using a SH3PXD2B Polyclonal Antibody (Product # PA5-57673) shows localization to nucleus and plasma membrane. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
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          View Product

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          SH3PXD2B Antibody in Immunocytochemistry (ICC/IF)
          SH3PXD2B Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SH3PXD2B Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SH3PXD2B Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SH3PXD2B Antibody in Immunohistochemistry (IHC)
          SH3PXD2B Antibody in Western Blot (WB)
          SH3PXD2B Antibody in Immunohistochemistry (IHC)
          SH3PXD2B Antibody in Western Blot (WB)
          SH3PXD2B Antibody
          SH3PXD2B Antibody
          SH3PXD2B Polyclonal Antibody

          Product Details

          PA5-57673

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          0.04-0.4 µg/mL
          View 1 publication 1 publication

          Immunohistochemistry (IHC)

          -
          View 1 publication 1 publication

          Immunohistochemistry (Paraffin) (IHC (P))

          1:200-1:500
          -

          Immunocytochemistry (ICC/IF)

          0.25-2 µg/mL
          -
          Product Specifications

          Species Reactivity

          Human

          Published species

          Human

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Recombinant protein corresponding to Human SH3PXD2B. Recombinant protein control fragment (Product #RP-96944).
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.1 mg/mL

          Amount

          10 µg

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.2, with 40% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2647252

          Product Specific Information

          Immunogen sequence: PPGVILPMMP AKHIPPARDS RRPEPKPDKS RLFQLKNDMG LECGHKVLAK EVKKPNLRPI SKSKTDLPEE KPDATPQNPF LKSRPQV

          Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 80%.

          Target Information

          Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: Adapter protein HOFI; adaptor protein HOFI; Factor for adipocyte differentiation 49; FLJ20831; homolog of FISH; SH3 and PX domain-containing protein 2B; Tyrosine kinase substrate with four SH3 domains; unnamed protein product

          View more View less

          Gene Aliases: FAD49; FTHS; HOFI; KIAA1295; SH3PXD2B; TKS4; TSK4

          View more View less

          UniProt ID: (Human) A1X283

          View more View less

          Entrez Gene ID: (Human) 285590

          View more View less

          Function(s)
          protein binding phosphatidylinositol-5-phosphate binding superoxide-generating NADPH oxidase activator activity phosphatidylinositol-3-phosphate binding phosphatidylinositol binding SH2 domain binding phosphatidylinositol-3,5-bisphosphate binding
          Process(es)
          skeletal system development eye development superoxide metabolic process heart development extracellular matrix disassembly cell differentiation superoxide anion generation bone development adipose tissue development podosome assembly protein localization to membrane
          It has to be done as per old AB suggested Products section.

          Disclaimer

          Close

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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