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Invitrogen
NCAPD2 Polyclonal Antibody
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Product Details
PA5-57886
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NCAPD2. Recombinant protein control fragment (Product #RP-97627).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DKSVLVCKNA IQLLASFLAN NPFSCKLSDA DLAGPLQKET QKLQEMRAQR RTAAASAVLD PEEEWEAMLP ELKSTLQQLL QLPQGEEEIP EQIA
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 88%.
Target Information
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chromosome condensation-related SMC-associated protein 1; Chromosome-associated protein D2; Condensin complex subunit 1; hCAP-D2; KIAA0159; Non-SMC condensin I complex subunit D2; unnamed protein product; XCAP-D2 homolog
Gene Aliases: CAP-D2; CAPD2; CNAP1; hCAP-D2; KIAA0159; MCPH21; NCAPD2
UniProt ID: (Human) Q15021
Entrez Gene ID: (Human) 9918
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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