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Invitrogen
CRY2 Polyclonal Antibody
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Product Details
PA5-58018
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CRY2. Recombinant protein control fragment (Product #RP-97323).
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Amount
60 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LLASVPSCVE DLSHPVAEPS SSQAGSMSSA GPRPLPSGPA SPKRKLEAAE EPPGEELSKR ARVAELPTPE LPSKDA
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 82%.
Target Information
Various biochemical, physiological and behavioral processes display circadian rhythms controlled by an internal biological clock. The central "gears" driving this clock appear to be composed of an autoregulatory transcription/post translation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function; in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cryptochrome 2 (photolyase-like); cryptochrome circadian clock 2; Cryptochrome-2; GIG37; growth-inhibiting protein 37; unnamed protein product
Gene Aliases: CRY2; HCRY2; KIAA0658; PHLL2
UniProt ID: (Human) Q49AN0
Entrez Gene ID: (Human) 1408
nucleotide binding
transcription regulatory region sequence-specific DNA binding
DNA binding
damaged DNA binding
single-stranded DNA binding
deoxyribodipyrimidine photo-lyase activity
DNA (6-4) photolyase activity
protein phosphatase inhibitor activity
protein binding
photoreceptor activity
blue light photoreceptor activity
ligand-dependent nuclear receptor binding
kinase binding
protein kinase binding
phosphatase binding
FAD binding
negative regulation of transcription from RNA polymerase II promoter
photoreactive repair
protein import into nucleus
circadian rhythm
response to light stimulus
blue light signaling pathway
response to activity
lipid storage
response to insulin
circadian regulation of gene expression
glucose homeostasis
regulation of circadian rhythm
negative regulation of circadian rhythm
entrainment of circadian clock by photoperiod
negative regulation of transcription, DNA-templated
rhythmic process
regulation of sodium-dependent phosphate transport
negative regulation of glucocorticoid receptor signaling pathway
negative regulation of glucocorticoid secretion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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