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Invitrogen
NSUN2 Polyclonal Antibody
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Product Details
PA5-58155
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NSUN2. Recombinant protein control fragment (Product #RP-96791).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PFVFIPEDDP LFPPIEKFYA LDPSFPRMNL LTRTTEGKKR QLYMVSKELR NVLLNNSEKM KVINTGIKVW CRNNSGEEFD CAFRLAQ
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
NSUN2 encodes a methyltransferase that catalyzes the intron-dependent formation of 5-methylcytosine at C34 of tRNA-leu(CAA). Maturation of cytoplasmic tRNAs includes splicing of introns, which are located 1 nucleotide 3-prime from the anticodon in all intron-containing tRNA genes. In tRNA-leu(CAA), the first position of the anticodon, C34, is converted to 5-methylcytosine, a modification necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Mutations of NSUN2 result in autosomal recessive 5 mental retardation (MRT5).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-methycytoisine methyltransferase; hTrm4; Misu; mRNA cytosine C(5)-methyltransferase; Myc-induced SUN domain-containing protein; Myc-induced SUN-domain-containing protein; NOL1/NOP2/Sun domain family member 2; NOL1/NOP2/Sun domain family, member 2; NOP2/Sun domain family, member 2; NOP2/Sun RNA methyltransferase family member 2; RNA cytosine C(5)-methyltransferase NSUN2; Substrate of AIM1/Aurora kinase B; tRNA (cytosine(34)-C(5))-methyltransferase; tRNA (cytosine-5-)-methyltransferase NSUN2; tRNA cytosine C(5)-methyltransferase; tRNA methyltransferase 4 homolog; unnamed protein product
Gene Aliases: MISU; MRT5; NSUN2; SAKI; TRM4
UniProt ID: (Human) Q08J23
Entrez Gene ID: (Human) 54888
RNA methylation
in utero embryonic development
mRNA processing
tRNA modification
spermatogenesis
spermatid development
tRNA processing
regulation of mRNA export from nucleus
cell differentiation
tRNA methylation
methylation
meiotic cell cycle checkpoint
tRNA stabilization
hair follicle maturation
cell division
regulation of stem cell differentiation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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