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Invitrogen
HIP1R Polyclonal Antibody
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Product Details
PA5-58260
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HIP1R. Recombinant protein control fragment (Product #RP-102810).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VVADLFDQTF GPPNGSVKDD RDLQIESLKR EVEMLRSELE KIKLEAQRYI AQLKSQVNAL EGELEEQRKQ KQKALVDNEQ LR
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 89%.
Target Information
Huntingtin disease, a neurodegenerate disease, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a reportedly proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it is likely to be involved in the recruitment of clathrin coats to lipid membranes and it may also factor in tumorigenesis by allowing the survival of precancerous and cancerous cells. Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a putative prognostic factor for prostate and colon cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HIP-12; HIP1-related protein; huntingtin interacting protein 12; Huntingtin-interacting protein 1-related protein; Huntingtin-interacting protein 12; unnamed protein product
Gene Aliases: HIP12; HIP1R; HIP3; ILWEQ; KIAA0655
UniProt ID: (Human) O75146
Entrez Gene ID: (Human) 9026
actin binding
protein binding
phospholipid binding
phosphatidylinositol-4,5-bisphosphate binding
phosphatidylinositol-3,4,5-trisphosphate binding
SH3 domain binding
clathrin binding
clathrin light chain binding
phosphatidylinositol binding
clathrin adaptor activity
identical protein binding
protein homodimerization activity
phosphatidylinositol-3,4-bisphosphate binding
protein heterodimerization activity
actin filament binding
phosphatidylinositol-3,5-bisphosphate binding
endocytosis
receptor-mediated endocytosis
actin filament organization
regulation of endocytosis
negative regulation of actin filament polymerization
regulation of actin cytoskeleton organization
negative regulation of Arp2/3 complex-mediated actin nucleation
regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of epidermal growth factor receptor signaling pathway
clathrin coat assembly
protein stabilization
positive regulation of transport
positive regulation of cellular component organization
digestive system development
regulation of gastric acid secretion
membrane organization
apoptotic signaling pathway
intrinsic apoptotic signaling pathway
postsynapse organization
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
positive regulation of clathrin coat assembly
regulation of clathrin-mediated endocytosis
positive regulation of platelet-derived growth factor receptor-beta signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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