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Invitrogen
VPS11 Polyclonal Antibody
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Product Details
PA5-58629
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human VPS11. Recombinant protein control fragment (Product #RP-97405).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: HQHCFESYSE SDADCPTCLP ENRKVMDMIR AQEQKRDLHD QFQHQLKCSN DSFSVIADYF GRGVFNKLTL LTDPPTARLT SSLEAGLQRD LLMHSR
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
Target Information
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hVPS11; RING finger protein 108; unnamed protein product; vacuolar protein sorting 11 homolog; Vacuolar protein sorting-associated protein 11 homolog; VPS11, CORVET/HOPS core subunit
Gene Aliases: DYT32; END1; HLD12; HLD12; DYT32; hVPS11; PEP5; PP3476; RNF108; VPS11
UniProt ID: (Human) Q9H270
Entrez Gene ID: (Human) 55823
intracellular protein transport
vesicle docking involved in exocytosis
autophagy
endosome organization
vacuole organization
endosome to lysosome transport
protein transport
vesicle-mediated transport
protein ubiquitination
regulation of protein stability
negative regulation of intracellular estrogen receptor signaling pathway
endosomal vesicle fusion
regulation of SNARE complex assembly
positive regulation of protein catabolic process
organelle fusion
regulation of organelle assembly
positive regulation of protein targeting to mitochondrion
positive regulation of early endosome to late endosome transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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