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Invitrogen
Agrin Polyclonal Antibody
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Product Details
PA5-59064
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Agrin. Recombinant protein control fragment (Product #RP-89940).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RYLKGKDLVA RESLLDGGNK VVISGFGDPL ICDNQVSTGD TRIFFVNPAP PYLWPAHKNE LMLNSSLMRI TLRNLEEVEF CVEDKPGTHF TPVPPTPPDA CRG
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 46%.
Target Information
Agrin is a molecule that resides in the basal lamina of muscle cells and directs key events in post synaptic differentiation. Most notably, Agrin is responsible for the clustering of acetylcholine receptors (AChRs) on the cell surface and their localization to the neuromuscular junction. Several Agrin variants have been identified which arise from alternative mRNA splicings. Agrin splice forms having inserts at two sites in the carboxy terminus designated "y" and "z" display a high affinity for AChRs, while splice forms lacking these inserts associate with AChRs weakly. Muscle alpha-dystroglycan has been postulated to be the receptor for the clustering activity of agrin; however, this is a point of contention. Tyrosine phosphorylation has been implicated as a required early step in AChR aggregation. Interestingly, a unique receptor tyrosine kinase, designated MuSK, has been discovered that interacts with Agrin and is specifically localized to developing muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Agrin; agrin proteoglycan; RP23-139J18.2; synaptic basal lamina component; unnamed protein product
Gene Aliases: AGRIN; AGRN; CMS8; CMSPPD
UniProt ID: (Human) Q5SVA2
Entrez Gene ID: (Human) 375790
cytoskeleton organization
signal transduction
G-protein coupled acetylcholine receptor signaling pathway
nervous system development
neuromuscular junction development
regulation of synaptic growth at neuromuscular junction
cell differentiation
receptor clustering
positive regulation of GTPase activity
clustering of voltage-gated sodium channels
positive regulation of synaptic growth at neuromuscular junction
positive regulation of transcription from RNA polymerase II promoter
synapse organization
positive regulation of filopodium assembly
membrane organization
synaptic signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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