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Invitrogen
ABCG4 Polyclonal Antibody
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Product Details
PA5-59139
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ABCG4. Recombinant protein control fragment (Product #RP-97473).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NPMLFRAVQN GLCAMAEKKS SPEKNEVPAP CPPCPPEVDP IESHTFATST LT
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 92%.
Target Information
The ABCG4 gene encodes the ATP-binding cassette sub-family G member 4, a protein that is part of the ABC transporter family involved in the transport of various molecules across cellular membranes. ABC transporters play essential roles in lipid transport, drug resistance, and the maintenance of cellular homeostasis. ABCG4, specifically, is known to be involved in the transport of cholesterol and other lipids, influencing lipid homeostasis and potentially impacting processes such as cholesterol efflux and cellular lipid balance. This protein is expressed in specific tissues, including the brain and retina, indicating its role in neuronal lipid metabolism and health. While its exact physiological functions are still being elucidated, alterations in ABCG4 expression or function may be implicated in lipid-related disorders and neurodegenerative diseases, where lipid metabolism plays a crucial part. Research into ABCG4 focuses on understanding its transport mechanisms and potential contributions to pathological states, aiming to develop targeted therapies that address imbalances in lipid and cholesterol metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-binding cassette sub-family G member 4; ATP-binding cassette, sub-family G (WHITE), member 4; putative ABC transporter; unnamed protein product
Gene Aliases: ABCG4; WHITE2
UniProt ID: (Human) Q9H172
Entrez Gene ID: (Human) 64137
regulation of transcription, DNA-templated
lipid transport
positive regulation of cholesterol efflux
sterol transport
cholesterol efflux
cholesterol homeostasis
positive regulation of cholesterol biosynthetic process
transmembrane transport
cellular response to high density lipoprotein particle stimulus
cellular response to leukemia inhibitory factor
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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