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Invitrogen
VPS18 Polyclonal Antibody
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Product Details
PA5-59255
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human VPS18. Recombinant protein control fragment (Product #RP-98057).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LYVNRNGQKV RPLARWKGQL VESVGWNKAL GTESSTGPIL VGTAQGHIFE AELSASEGGL FGPAPDLYFR PLYVLNEEGG PAPVCSLEAE RGPDGRSFVI ATT
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 95%.
Target Information
VPS18 is a vesicle mediated protein that plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hVPS18; vacuolar protein sorting 18 homolog; vacuolar protein sorting protein 18; Vacuolar protein sorting-associated protein 18 homolog; VPS18, CORVET/HOPS core subunit
Gene Aliases: KIAA1475; PEP3; VPS18
UniProt ID: (Human) Q9P253
Entrez Gene ID: (Human) 57617
intracellular protein transport
vesicle docking involved in exocytosis
autophagy
endosome organization
lysosome organization
endosome to lysosome transport
protein transport
vesicle-mediated transport
protein ubiquitination
negative regulation of intracellular estrogen receptor signaling pathway
endosomal vesicle fusion
regulation of SNARE complex assembly
viral entry into host cell
organelle fusion
regulation of synaptic vesicle exocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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