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Invitrogen
KCTD4 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-59272
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human KCTD4. Recombinant protein control fragment (Product #RP-98002).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LNFLRNGELL LPEGFRENQL LAQEAEFFQL KGLAEEVKSR WEKEQLTPRE TTFLEITDNH DRSQGLRIFC NAPDF
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 99%.
Target Information
The KCTD4 (Potassium Channel Tetramerization Domain Containing 4) gene encodes a protein involved in various cellular processes, including the regulation of calcium homeostasis and modulation of fibroblast activity. KCTD4 interacts with chloride intracellular channel 1 (CLIC1) to disrupt calcium homeostasis, leading to increased fibronectin secretion, which activates fibroblasts via paracrine signaling. This activation can promote cancer cell invasion through matrix metalloproteinase 24 (MMP24) signaling. The interaction between KCTD4 and CLIC1 presents a potential target for therapeutic strategies, as inhibition of this interaction has been shown to significantly suppress cancer metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: potassium channel tetramerisation domain containing 4; unnamed protein product
Gene Aliases: bA321C24.3
UniProt ID: (Human) Q8WVF5
Entrez Gene ID: (Human) 386618
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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