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Invitrogen
SPIRE1 Polyclonal Antibody
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Product Details
PA5-59362
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SPIRE1. Recombinant protein control fragment (Product #RP-98282).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LQRGESSMRS EKPSTAHHRP LRSIARFSSK SKSMDKSDEE LQFPKELMED WSTMEVCVDC KKFISEIISS SRRSLVLANK RARLKRKTQ
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.
Target Information
Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein spire homolog 1; Spir-1; spire actin nucleation factor 1; spire family actin nucleation factor 1; spire homolog 1; unnamed protein product
Gene Aliases: KIAA1135; Spir-1; SPIR1; SPIRE1
UniProt ID: (Human) Q08AE8
Entrez Gene ID: (Human) 56907
immune system process
protein transport
vesicle-mediated transport
actin cytoskeleton organization
cleavage furrow formation
polar body extrusion after meiotic divisions
actin nucleation
innate immune response
intracellular transport
Golgi vesicle transport
establishment of meiotic spindle localization
actin filament network formation
formin-nucleated actin cable assembly
positive regulation of mitochondrial fission
positive regulation of double-strand break repair
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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