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Invitrogen
RNF40 Polyclonal Antibody
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Product Details
PA5-59519
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RNF40. Recombinant protein control fragment (Product #RP-98596).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: AVSRVVEASD RLQRRVEELC QRVYSRGDSE PLSEAAQAHT RELGRENRRL QDLATQLQEK HHRISLEYSE LQDKVTSAET KVLEME
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 91%.
Target Information
The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 95 kDa retinoblastoma protein binding protein; 95 kDa retinoblastoma-associated protein; BRE1 E3 ubiquitin ligase homolog B; BRE1-B; DKFZp686K191; E3 ubiquitin-protein ligase BRE1B; MGC13051; Protein staring; Rb-associated protein; RBP95; RING finger protein 40; ring finger protein 40, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase BRE1B; staring protein; Syntaxin-1-interacting RING finger protein; unnamed protein product
Gene Aliases: AI848422; BRE1B; KIAA0661; mKIAA0661; RBP95; RNF40; STARING
UniProt ID: (Human) O75150, (Rat) Q8CJB9, (Mouse) Q3U319
Entrez Gene ID: (Human) 9810, (Rat) 266712, (Mouse) 233900
mRNA 3'-UTR binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
ubiquitin protein ligase binding
protein homodimerization activity
metal ion binding
ubiquitin protein ligase activity
ligase activity
syntaxin-1 binding
protein complex binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
ubiquitin conjugating enzyme binding
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-dependent protein catabolic process
regulation of mitotic cell cycle
histone monoubiquitination
histone H2B ubiquitination
negative regulation of mRNA polyadenylation
positive regulation of histone H2B ubiquitination
chromatin organization
protein ubiquitination
positive regulation of transcription from RNA polymerase II promoter
chromatin modification
positive regulation of proteasomal protein catabolic process
positive regulation of protein polyubiquitination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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