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Invitrogen
DUOXA1 Polyclonal Antibody
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Product Details
PA5-59634
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DUOXA1. Recombinant protein control fragment (Product #RP-98473).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VAHRMQPHRL KAFFNQSVDE DPMLEWSPEE GGLLSPRYRS MADSPKSQDI PLSEASS
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 79%.
Target Information
Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dual oxidase activator 1; Dual oxidase maturation factor 1; dual oxidase maturation factor 1 alpha; dual oxidase maturation factor 1 beta; dual oxidase maturation factor 1 delta; dual oxidase maturation factor 1 gamma; duoxa1 alpha; duoxa1 beta; inactive variant; duoxa1 delta; inactive variant; duoxa1 gamma; homolog of Drosophila Numb-interacting protein; Numb-interacting protein; unnamed protein product
Gene Aliases: DUOXA1; mol; NIP; NUMBIP
UniProt ID: (Human) Q1HG43
Entrez Gene ID: (Human) 90527
protein localization
positive regulation of hydrogen peroxide biosynthetic process
protein transport
hydrogen peroxide metabolic process
positive regulation of neuron differentiation
regulation of inflammatory response
positive regulation of reactive oxygen species metabolic process
regulation of thyroid hormone generation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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