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Invitrogen
RASGRF1 Polyclonal Antibody
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Product Details
PA5-59803
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RASGRF1. Recombinant protein control fragment (Product #RP-98034).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RKLSLNIPII TGGKALDLAA LSCNSNGYTS MYSAMSPFSK ATLDTSKLYV SSSFTNKIPD EGDTTPEKPE DPSALSKQSS EVSMREESDI DQNQSDDGDT E
Highest antigen sequence identity to the following orthologs: Mouse - 58%, Rat - 55%.
Target Information
RASGRF1 is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. Studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ASPP1; CDC25; CDC25 homolog; CDC25 like; GNRP; guanine nucleotide exchange factor; guanine nucleotide-releasing factor 1; guanine nucleotide-releasing factor, 55 kD; Guanine nucleotide-releasing protein; KIAA0771; PPP1R13B; Ras-GRF1; Ras-specific guanine nucleotide-releasing factor 1; Ras-specific guanine nucleotide-releasing factor, CDC25 homolog; Ras-specific nucleotide exchange factor CDC25; unnamed protein product
Gene Aliases: CDC25; CDC25L; GNRP; GRF1; GRF55; H-GRF55; PP13187; ras-GRF1; RASGRF1
UniProt ID: (Human) Q13972
Entrez Gene ID: (Human) 5923
signal transduction
small GTPase mediated signal transduction
Ras protein signal transduction
long-term memory
neuron projection development
response to endoplasmic reticulum stress
positive regulation of Rac protein signal transduction
intracellular signal transduction
negative regulation of MAPK cascade
positive regulation of MAPK cascade
type B pancreatic cell proliferation
regulation of Ras protein signal transduction
positive regulation of Ras protein signal transduction
regulation of synaptic plasticity
regulation of neuronal synaptic plasticity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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