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Invitrogen
ELOVL6 Polyclonal Antibody
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Product Details
PA5-59954
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ELOVL6. Recombinant protein control fragment (Product #RP-91275).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VLTLQEYEFE KQFNENEAIQ WMQENWKKS
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
Lipogenesis is a key event in the energy storage system and is controlled by the transcription factor sterol regulatory element-binding protein (SREBP)-1. Elongation of very long chain fatty acids protein 6 (ELOVL6) is a member of fatty acyl-CoA elongase gene family that converts palmitic to stearic acid and it has been shown to be a target of SREBP-1, playing an important role in de novo synthesis of long-chain saturated and monosaturated fatty acids in conjunction with fatty acid synthase and stearoyl-CoA desaturase ELOVL6 was predicted to be important for tissue fatty acid composition. Recent studies suggest that inhibition of this elongase could be a new therapeutic approach for ameliorating insulin resistance, diabetes and cardiovascular risks, even in the presence of a continuing state of obesity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3-keto acyl-CoA synthase ELOVL6; Elongation of very long chain fatty acids protein 6; ELOVL FA elongase 6; ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast); ELOVL fatty acid elongase 6; Fatty acid elongase 2; Fatty acyl-CoA elongase; hELO2; Long-chain fatty-acyl elongase; unnamed protein product; Very long chain 3-ketoacyl-CoA synthase 6; Very long chain 3-oxoacyl-CoA synthase 6; Very long chain fatty acid elongase 6
Gene Aliases: ELOVL6; FACE; FAE; hELO2; LCE
UniProt ID: (Human) Q9H5J4
Entrez Gene ID: (Human) 79071
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
unsaturated fatty acid biosynthetic process
fatty acid elongation, saturated fatty acid
sphingolipid biosynthetic process
fatty acid elongation
fatty acid elongation, monounsaturated fatty acid
fatty acid elongation, polyunsaturated fatty acid
long-chain fatty-acyl-CoA biosynthetic process
long-chain fatty acid biosynthetic process
very long-chain fatty acid biosynthetic process
positive regulation of cold-induced thermogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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