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Invitrogen
NAIP Polyclonal Antibody
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Product Details
PA5-59978
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NAIP. Recombinant protein control fragment (Product #RP-92089).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KSGIQCFCCS LILFGAGLTR LPIEDHKRFH PDCGFLLNKD VGNIAKYDIR VKNLKSRLRG GKMRYQEEEA RLASFRNWPF YVQGISPCVL SEAGFVFTGK QD
Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 66%.
Target Information
Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy. Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR); these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules (reviewed in 3). Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO, suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Baculoviral IAP repeat-containing protein 1; FLJ18088; FLJ42520; FLJ58811; Neuronal apoptosis inhibitory protein; nucleotide-binding oligomerization domain, leucine rich repeat and BIR domain containing 1; psi neuronal apoptosis inhibitory protein; unnamed protein product
Gene Aliases: BIRC1; NAIP; NLRB1; psiNAIP
UniProt ID: (Human) Q13075
Entrez Gene ID: (Human) 4671
pattern recognition receptor signaling pathway
immune system process
apoptotic process
inflammatory response
nervous system development
negative regulation of tumor necrosis factor-mediated signaling pathway
detection of bacterium
positive regulation of interleukin-1 beta production
defense response to bacterium
regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
innate immune response
positive regulation of JNK cascade
icosanoid biosynthetic process
positive regulation of inflammatory response
pyroptosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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