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Invitrogen
AKAP8L Polyclonal Antibody
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Product Details
PA5-59993
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human AKAP8L. Recombinant protein control fragment (Product #RP-98865).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DEEGKEDGRE EGKEDPEKGA LTTQDENGQT KRKLQAGKKS QDKQKKRQRD RMVERIQFVC SLCKYRTFYE DEMASHLDSK FHKEHFKYVG TKLPKQTAD
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.
Target Information
Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A kinase (PRKA) anchor protein 8-like; A-kinase anchor protein 8-like; AKAP8-like protein; HA95; HAP95; Helicase A-binding protein 95; helicase A-binding protein 95 kDa; Homologous to AKAP95 protein; neighbor of A-kinase anchoring protein 95; Neighbor of A-kinase-anchoring protein 95; neighbor of AKAP; Neighbor of AKAP95; testis tissue sperm-binding protein Li 90mP
Gene Aliases: AKAP8L; HA95; HAP95; HRIHFB2018; NAKAP; NAKAP95
UniProt ID: (Human) Q9ULX6
Entrez Gene ID: (Human) 26993
transcription, DNA-templated
mRNA processing
mitotic chromosome condensation
biological_process
RNA splicing
regulation of mRNA export from nucleus
positive regulation of histone deacetylation
regulation of histone phosphorylation
cell cycle G2/M phase transition
positive regulation of transcription from RNA polymerase II promoter
nuclear envelope disassembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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