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Invitrogen
CACTIN Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-60003
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CACTIN. Recombinant protein control fragment (Product #RP-98976).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TGFEWNKYNQ THYDFDNPPP KIVQGYKFNI FYPDLIDKRS TPEYFLEACA DNKDFAILRF HAGPPYEDIA FKIVNREWEY SHRHGFRCQF ANGIFQLWFH
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
Target Information
Cactin is a novel negative regulator of TLR signaling and reveals its capacity to target MHC Class III genes at the molecular and functional level. It is localized to the nucleus, which is critical for manifesting its inhibitory effects on TLR signaling. Experimental evidences show overexpression of Cactin suppresses TLR-induced activation of NF-kB and interferon-regulatory factor transcription factors and induction of TLR-responsive genes. It is also reported Cactin interacts with IkB-like protein and targets other proteins that are encoded by genes in the MHC Class III region of chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: functional spliceosome-associated protein c; NY REN 24 antigen; NY-REN-24 antigen; Renal carcinoma antigen NY-REN-24; Splicing factor Cactin; unnamed protein product
Gene Aliases: C19orf29; CACTIN; fSAPc; NY-REN-24
UniProt ID: (Human) Q8WUQ7
Entrez Gene ID: (Human) 58509
mRNA splicing, via spliceosome
negative regulation of protein phosphorylation
immune system process
mRNA processing
RNA splicing
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of NF-kappaB transcription factor activity
negative regulation of interferon-beta production
negative regulation of interleukin-8 production
negative regulation of tumor necrosis factor production
negative regulation of toll-like receptor signaling pathway
negative regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
mRNA cis splicing, via spliceosome
negative regulation of innate immune response
negative regulation of type I interferon-mediated signaling pathway
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to tumor necrosis factor
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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