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Invitrogen
ERMAP Polyclonal Antibody
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Product Details
PA5-60029
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ERMAP. Recombinant protein control fragment (Product #RP-98529).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PLVICSELHK SEESIVPRPE GKGHANGDVS LKVNSSLLPP KAPELKDIIL SLPPDLGPAL QELKAPS
Highest antigen sequence identity to the following orthologs: Mouse - 63%, Rat - 64%.
Target Information
Erythroblast membrane-associated protein (ERMAP) is a gene situated on chromosome 1p34.2, encoding a protein primarily associated with erythroblast cells. ERMAP is expressed in erythroid lineage cells and plays a crucial role as an adhesion molecule, involved in the maturation and stability of the erythrocyte membrane. This protein is associated with the Scianna blood group system, and variations within the ERMAP gene lead to different antigenic expressions which are important in transfusion medicine. ERMAP is also significant in mediating cell-cell adhesion processes essential for erythropoiesis, where it facilitates receptor-ligand interactions in hematopoietic stem cells. Mutations or polymorphisms in ERMAP can result in altered blood group antigens, impacting blood transfusion compatibility and potentially leading to hemolytic reactions. Given its distinct role in erythrocyte formation, ERMAP is a subject of interest for further research into blood-related disorders and their genetic underpinnings.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ERMAP; type 1 transmembrane protein; likely adhesion/receptor protein; Erythroid membrane-associated protein; hERMAP; MGC118810; MGC118811; Radin blood group; Radin blood group (Rd); Radin blood group antigen; RDMGC118812; Scianna blood group; Scianna blood group (Sc); Scianna blood group antigen; SCMGC118813; unnamed protein product
Gene Aliases: BTN5; ERMAP; PRO2801; RD; SC
UniProt ID: (Human) Q96PL5
Entrez Gene ID: (Human) 114625
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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