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Invitrogen
TTLL10 Polyclonal Antibody
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Product Details
PA5-60090
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TTLL10. Recombinant protein control fragment (Product #RP-99825).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KPTASNQGKG IFLLRNQEEV AALQAKTRSM EDDPIHHKTP FRGPQARVVQ RYIQNPLLVD GRKFDVRSYL LIACTTPYMI FFGHGYARLT LSLYDPHSSD LG
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 82%.
Target Information
The TTLL10 gene encodes a protein that functions as a polyglycylase, playing an important role in the modification of nucleosome assembly protein 1 (NAP1) both in vivo and in vitro. This enzymatic activity is dependent on the presence of ATP and is abolished in mutant forms where the glutamate in the active site is replaced by valine. TTLL10 specifically incorporates glycine into recombinant NAP1 at Glu residues 359 and 360. This modification process likely has implications for protein interactions and cellular processes involving NAP1. Additionally, TTLL10 can perform tubulin glycylation when co-expressed with TTLL8, suggesting a complex interplay between these enzymes in cellular microtubule dynamics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Inactive polyglycylase TTLL10; tubulin tyrosine ligase-like family member 10; tubulin tyrosine ligase-like family, member 10; tubulin tyrosine ligase-like family, member 5; Tubulin--tyrosine ligase-like protein 10
Gene Aliases: TTLL10; TTLL5
UniProt ID: (Human) Q6ZVT0
Entrez Gene ID: (Human) 254173
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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