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Invitrogen
ECSIT Polyclonal Antibody
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Product Details
PA5-60183
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ECSIT. Recombinant protein control fragment (Product #RP-99074).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: HMEPDLSARV TIYQVPLPKD STGAADPPQP HIVGIQSPDQ QAALARHNPA RPVFVEGPFS LWLRNKCVYY HILRADLLPP EEREVEETPE EWNLYYPM
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 85%.
Target Information
Activation of NF-kappa-B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 to kinases such as IRAK and other intermediates such as TNF receptor associated factor (TRAF)-6. ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway. Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ECSIT homolog; Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved; Protein SITPEC; signaling intermediate in Toll pathway-evolutionarily conserved
Gene Aliases: ECSIT; SITPEC
UniProt ID: (Human) Q9BQ95, (Rat) Q5XIC2, (Mouse) Q9QZH6
Entrez Gene ID: (Human) 51295, (Rat) 300447, (Mouse) 26940
mitochondrial respiratory chain complex I assembly
innate immune response
regulation of oxidoreductase activity
oxidation-reduction process
mesoderm formation
regulation of transcription from RNA polymerase II promoter
transmembrane receptor protein serine/threonine kinase signaling pathway
BMP signaling pathway
immune system process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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