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Invitrogen
NALP12 Polyclonal Antibody
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Product Details
PA5-60185
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NALP12. Recombinant protein control fragment (Product #RP-99104).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LKRCRSAQVL HLYGATYSAD GEDRARCSAG AHTLLVQLPE RTVLLDAYSE HLAAALCTNP NLIELSLYRN ALGS
Highest antigen sequence identity to the following orthologs: Mouse - 54%, Rat - 53%.
Target Information
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappa-B activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: monarch 1; Monarch-1; NACHT, LRR and PYD domains-containing protein 12; NLR family, pyrin domain containing 12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; PYRIN-containing APAF1-like protein 7; Regulated by nitric oxide
Gene Aliases: CLR19.3; FCAS2; NALP12; NLRP12; PAN6; PYPAF7; RNO; RNO2
UniProt ID: (Human) P59046
Entrez Gene ID: (Human) 91662
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
release of cytoplasmic sequestered NF-kappaB
negative regulation of signal transduction
negative regulation of protein autophosphorylation
negative regulation of NF-kappaB transcription factor activity
dendritic cell migration
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of MHC class I biosynthetic process
regulation of interleukin-18 biosynthetic process
negative regulation of interleukin-6 biosynthetic process
negative regulation of Toll signaling pathway
negative regulation of cytokine secretion
negative regulation of interleukin-1 secretion
positive regulation of interleukin-1 beta secretion
negative regulation of inflammatory response
positive regulation of inflammatory response
negative regulation of ERK1 and ERK2 cascade
cellular response to cytokine stimulus
negative regulation of NIK/NF-kappaB signaling
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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