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Invitrogen
HERC5 Polyclonal Antibody
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Product Details
PA5-60556
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HERC5. Recombinant protein control fragment (Product #RP-96656).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SKIKLLHTDT LLKIESKKHK AYLRSAAIEE ERESEFALRP TFDLTVRRNH LIEDVLNQLS QFENEDLRKE LWVSFSGEIG YDLGGVKKEF FYCLFA
Highest antigen sequence identity to the following orthologs: Mouse - 44%, Rat - 43%.
Target Information
HERC5 (E3 ISG15 - protein ligase HERC5) is a major E3 ligase for ISG15 conjugation. It acts a positive regulator of innate antiviral response in cells induced by interferon. HERC5 functions as a part of the ISGylation machinery that recognizes target protein in a broad and relatively non-specific manner. It catalyzes ISGylation of IRF3 - which results in sustained activation, it attenuates IRF3-PIN1 interaction - which antagonizes IFR3 ubiquitination and degradation, and boosts the antiviral repsonse. HERC5 is physically assocated with polyribosomes and broadly modifies newly synthesized proteins in a cotranslational manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cyclin-E-binding protein 1; E3 ISG15--protein ligase HERC5; HECT domain and RCC1-like domain-containing protein 5; hect domain and RLD 5; probable E3 ubiquitin-protein ligase HERC5; ubiquitin ligase; unnamed protein product
Gene Aliases: CEB1; CEBP1; HERC5
UniProt ID: (Human) Q9UII4
Entrez Gene ID: (Human) 51191
regulation of cyclin-dependent protein serine/threonine kinase activity
immune system process
ubiquitin-dependent protein catabolic process
protein ubiquitination
ISG15-protein conjugation
PKR/eIFalpha signaling
innate immune response
regulation of defense response to virus
defense response to virus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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