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Invitrogen
GPR41 Polyclonal Antibody
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Product Details
PA5-60791
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GPR41. Recombinant protein control fragment (Product #RP-100019).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DFHELLRRLC GLWGQWQQES SMELKEQKGG EEQRADRPAE RKTSEHSQGC GTGGQVAC
Highest antigen sequence identity to the following orthologs: Mouse - 32%, Rat - 33%.
Target Information
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. GPRs translate extracellular signals into intracellular signals (a process called G-protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR41 (G-protein coupled receptor 41), also known as FFAR3 (Free fatty acid receptor 3), is a 346 amino acid multi-pass membrane protein that belongs to the G protein-coupled receptor family. Expressed at high levels in adipose tissue and at lower levels throughout the body, GPR41 functions as a receptor for short chain fatty acids via elevation of intracellular calcium levels and inhibition of adenylyl cyclase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Free fatty acid receptor 3; G protein-coupled receptor 41; G-protein coupled receptor 41; Gpcr41
Gene Aliases: FFA3R; FFAR3; GPR41; GPR42
UniProt ID: (Human) O14843
Entrez Gene ID: (Human) 2865
mucosal immune response
positive regulation of cytokine production involved in immune response
positive regulation of acute inflammatory response to non-antigenic stimulus
inflammatory response
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
regulation of norepinephrine secretion
positive regulation of chemokine production
negative regulation of blood pressure
regulation of hormone biosynthetic process
cellular response to fatty acid
regulation of peptide hormone secretion
positive regulation of glucose import in response to insulin stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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