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Invitrogen
PUS10 Polyclonal Antibody
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Product Details
PA5-60808
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PUS10. Recombinant protein control fragment (Product #RP-99687).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LVKQEMGKQS LSLGRDDIVQ LKEAYKWITH PLFSEELGVP IDGKSLFEVS VVFAHPETVE DCHFLAAICP DCFKPAKNKQ SVFTRMAVMK A
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.
Target Information
Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: coiled-coil domain containing 139; Coiled-coil domain-containing protein 139; Hup10; pseudouridine synthase 10; Psi55 synthase; tRNA pseudouridine 55 synthase; tRNA pseudouridine synthase Pus10; tRNA pseudouridylate synthase; tRNA-uridine isomerase
Gene Aliases: CCDC139; DOBI; PUS10
UniProt ID: (Human) Q3MIT2
Entrez Gene ID: (Human) 150962
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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