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Invitrogen
UBXN2B Polyclonal Antibody
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Product Details
PA5-60969
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human UBXN2B. Recombinant protein control fragment (Product #RP-100343).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GEQERRSSGP RPPSARDLQL ALAELYEDEV KCKSSKSNRP KATVFKSPRT PPQRFYSSEH EYSGLNIVRP S
Highest antigen sequence identity to the following orthologs: Mouse - 69%, Rat - 75%.
Target Information
UBXD2B (UBX domain-containing protein 2B), also known as NSFL1 cofactor p37 and p97 cofactor p37, is a 331 amino acid protein that contains one UBX domain and one SEP domain. UBXN2B is required for ER and Golgi biogenesis and also plays a role in their maintenance during interphase, as well as their reassembly at the end of mitosis. Through interaction with VCP, UBXN2B forms a complex that has membrane fusion activity. Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: NSFL1 cofactor p37; p97 cofactor p37; UBX domain-containing protein 2B; unnamed protein product
Gene Aliases: p37; UBXN2B
UniProt ID: (Human) Q14CS0
Entrez Gene ID: (Human) 137886
autophagosome assembly
establishment of mitotic spindle orientation
Golgi organization
nuclear envelope reassembly
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of mitotic centrosome separation
membrane fusion
negative regulation of protein localization to centrosome
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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