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Invitrogen
UCMA Polyclonal Antibody
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Product Details
PA5-61295
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human UCMA. Recombinant protein control fragment (Product #RP-100763).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: YYEEQRNEFE NFVEEQNDEQ EERSREAVEQ WRQWHYDGLH PSYLYNRHHT
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.
Target Information
UCMA is a gene that encodes for a protein that is specific to chondrocytes and highly charged. This protein is expressed abundantly in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the protein has been associated with osteoarthritis in humans. Alternative splicing of the gene results in multiple transcript variants that encode different isoforms. UCMA is also associated with diseases such as Osteoarthritis and Poland Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Gla-rich protein; Unique cartilage matrix-associated protein
Gene Aliases: C10orf49; GRP; GRP/UCMA; UCMA
UniProt ID: (Human) Q8WVF2
Entrez Gene ID: (Human) 221044
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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