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Invitrogen
PDE10A Polyclonal Antibody
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Product Details
PA5-61465
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PDE10A. Recombinant protein control fragment (Product #RP-90662).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TVEKWLKRKN NKSEDESAPK EVSRYQDTNM QGVVYELNSY IEQRLDTGGD NQLLLYELSS IIKIATKADG FALYFLGECN NSLCIFTPPG IKEGKPRLIP AGPITQGTTV SAYVAKSRKT LLVEDILGDE RFPRGTGLES GTRIQSVL
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 94%.
Target Information
Various cellular responses are regulated by the second messengers cAMP and cGMP. Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3',5' cAMP/cGMP phosphodiesterase; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; dJ416F21.1 (phosphodiesterase 10A); FLJ11894; FLJ25677; PDE10A; phosphodiesterase 10A1 (PDE10A1); phosphodiesterase 10A7 (PDE10A7); unnamed protein product
Gene Aliases: ADSD2; HSPDE10A; IOLOD; LINC00473; PDE10A; PDE10A19
UniProt ID: (Human) Q9Y233
Entrez Gene ID: (Human) 10846
nucleotide binding
catalytic activity
cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
phosphoric diester hydrolase activity
hydrolase activity
cAMP binding
cGMP binding
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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