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Invitrogen
SFRP4 Polyclonal Antibody
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Product Details
PA5-62219
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SFRP4. Recombinant protein control fragment (Product #RP-103081).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PTLATYLSKN YSYVIHAKIK AVQRSGCNEV TTVVDVKEIF KSSSPIPRTQ VPLITNSSCQ CPHILPHQDV LIMCYEWRSR MMLLENCLVE KWRDQLSKRS IQWEERLQEQ RRTVQDKKKT AGRTSRSNPP KPKGKPPAPK PASPK
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.
Target Information
Secreted Frizzled-Related Proteins (sFRPs) are a family of glycosylated Wnt antagonists characterized by a conserved cysteine-rich domain that shares homology with the cysteine-rich, extracellular domain Frizzled proteins use for the binding of Wnt proteins and receptors. Lacking the transmembrane and intracellular domains of the Frizzled proteins, sFRPs function as soluble modulators of the Wnt signaling pathway through the direct binding of Wnt proteins to this cysteine-rich domain, and the resultant inhibition of Wnt receptor binding and signaling capabilities. sFRP-4 is widely distributed in a variety of embryonic and adult tissues where it can function as a circulating antiangiogenic factor, a potent proapoptotic factor, an inhibitor of insulin secretion, and a suppressor of both tumor growth and metastatic potential through disruption of the Wnt signaling pathway. Research has demonstrated the existence of a direct correlation between the downregulation and/or absence of circulating sFRP-4 and the progression of several cancer types, including ovarian, endometrial, prostate and lung. Upregulation of circulating sFRP-4 has been linked to the deterioration of glucose metabolism in the case of type 2 diabetes, as well as the suppression of the keratinocyte hyperproliferation and epidermal hyperlasia that are definitive of psoriasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Frizzled protein, human endometrium; frizzled related protein; FrpHE; MGC26498; Secreted frizzled-related protein 4; secreted frizzled-related protein 4; secreted frizzled-related protein 4; sFRP-4; SFRP4; unnamed protein product
Gene Aliases: FRP-4; FRPHE; FRZB-2; PYL; sFRP-4; SFRP4
UniProt ID: (Human) Q6FHJ7
Entrez Gene ID: (Human) 6424
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
positive regulation of receptor internalization
negative regulation of cell proliferation
response to hormone
organ morphogenesis
positive regulation of gene expression
Wnt signaling pathway
cell differentiation
negative regulation of Wnt signaling pathway
regulation of BMP signaling pathway
non-canonical Wnt signaling pathway
positive regulation of apoptotic process
positive regulation of epidermal cell differentiation
phosphate ion homeostasis
canonical Wnt signaling pathway
bone morphogenesis
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
positive regulation of keratinocyte apoptotic process
negative regulation of non-canonical Wnt signaling pathway
negative regulation of sodium-dependent phosphate transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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