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Invitrogen
AKAP5 Polyclonal Antibody
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Product Details
PA5-62863
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human AKAP5. Recombinant protein control fragment (Product #RP-103170).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LDIQTQTPLN DQATKAKSTQ DLSEGISRKD GDEVCESNVS NSITSGEKVI SVELGLDNGH SAIQTGTLIL EEIE
Highest antigen sequence identity to the following orthologs: Mouse - 53%, Rat - 42%.
Target Information
AKAPs (A-kinase anchoring proteins), as their name implies, are a family of scaffolding proteins that bind regulatory subunits of Protein Kinase A (PKA) thus localizing PKA activity to distinct regions of the cell. Beyond a common amphipathic alpha helix that is responsible for recruiting the PKA regulatory subunit (RI alpha, RII alpha, RI beta, or RII beta), individual AKAPs contain additional domains responsible for the recrutiment of additional signaling proteins (phosphodiesterases, phosphatases, cytoskeletal components, other kinase, etc.) or restricting AKAP to a specific subcellular location. AKAP5 (also known as P75, AKAP75, or AKAP79) is predominantly expressed in neuronal tissues and cells where it serves to localize type II PKA to post-synaptic densities. AKAP5 specifically binds to the regulatory subunit of PKAII beta, anchoring the enzyme to the plasma membrane and sites of cytoskeletal/membrane junctions. The other binding domains of AKAP5 have been shown to interact with calmodulin, PP2B, and calcineurin suggesting that AKAP5 may act to coordinate the cAMP- and Ca2+-sensing pathways in various cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A kinase (PRKA) anchor protein 5; A-kinase anchor protein 5; A-kinase anchor protein 79 kDa; A-kinase anchoring protein 75/79; AKAP 5; AKAP 79; AKAP-5; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein; H21; unnamed protein product
Gene Aliases: AKAP5; AKAP75; AKAP79; H21
UniProt ID: (Human) P24588
Entrez Gene ID: (Human) 9495
protein binding
calmodulin binding
adenylate cyclase binding
SH3 domain binding
protein phosphatase 2B binding
beta-2 adrenergic receptor binding
protein kinase A regulatory subunit binding
glutamate receptor binding
GABA receptor binding
protein kinase A binding
binding, bridging
scaffold protein binding
signal transduction
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
chemical synaptic transmission
regulation of protein kinase A signaling
calcineurin-NFAT signaling cascade
positive regulation of calcineurin-NFAT signaling cascade
positive regulation of long-term synaptic potentiation
positive regulation of protein localization to plasma membrane
positive regulation of calcium ion import across plasma membrane
positive regulation of endosome to plasma membrane protein transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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