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Invitrogen
MBTPS1 Polyclonal Antibody
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Product Details
PA5-63247
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MBTPS1. Recombinant protein control fragment (Product #RP-104051).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: YPPGYFPRDN LRMKNDPLDW NGDHIHTNFR DMYQHLRSMG YFVEVLGAPF TCFDASQYGT LLMVDSEEEY FPEEIAKLRR DVDNGLSLVI FSDWYNTSVM RKVKFYDENT RQWWMPDTGG ANIPALNELL SV
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 97%.
Target Information
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Endopeptidase S1P; KIAA0091; Membrane-bound transcription factor site-1 protease; proprotein convertase subtilisin/kexin type 8; site-1 protease; SKI-1; subtilisin/kexin isozyme-1; Subtilisin/kexin-isozyme 1; unnamed protein product
Gene Aliases: KIAA0091; MBTPS1; PCSK8; S1P; SEDKF; SKI-1; SKI1
UniProt ID: (Human) Q14703
Entrez Gene ID: (Human) 8720
proteolysis
protein import into nucleus
NLS-bearing protein import into nucleus
lipid metabolic process
lysosome organization
mitotic G2 DNA damage checkpoint
steroid metabolic process
cholesterol metabolic process
protein processing
endoplasmic reticulum unfolded protein response
membrane protein intracellular domain proteolysis
response to endoplasmic reticulum stress
ATF6-mediated unfolded protein response
regulation of cholesterol biosynthetic process
positive regulation of cholesterol biosynthetic process
protein maturation
regulation of vesicle-mediated transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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