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Invitrogen
DTX4 Polyclonal Antibody
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Product Details
PA5-63346
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DTX4. Recombinant protein control fragment (Product #RP-101733).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TSPPMSPCSC PQCVLVMSVK AAVVNGSTGP LQLPVTRKNM PPPGVVKLP
Highest antigen sequence identity to the following orthologs: Mouse - 71%, Rat - 73%.
Target Information
DTX4 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. It functions as an ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: deltex 4 homolog; deltex 4, E3 ubiquitin ligase; deltex homolog 4; Deltex4; E3 ubiquitin-protein ligase DTX4; Protein deltex-4; RING finger protein 155; RING-type E3 ubiquitin transferase DTX4
Gene Aliases: DTX4; KIAA0937; RNF155
UniProt ID: (Human) Q9Y2E6
Entrez Gene ID: (Human) 23220
Notch signaling pathway
proteasomal protein catabolic process
protein ubiquitination
regulation of type I interferon production
proteasome-mediated ubiquitin-dependent protein catabolic process
innate immune response
negative regulation of innate immune response
protein K48-linked ubiquitination
antiviral innate immune response
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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