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Invitrogen
ACD Polyclonal Antibody
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Product Details
PA5-63463
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ACD. Recombinant protein control fragment (Product #RP-98544).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: IRELILGSET PSSPRAGQLL EVLQDAEAAV AGPSHAPDTS DVGATLLVSD GTHSVRCLVT REALDTSDWE EKEFGFRGTE GRLLLLQDCG VHVQVA
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 79%.
Target Information
This gene encodes a uridine 5' -monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5' -monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5' -monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adrenocortical dysplasia protein homolog; POT1 and TIN2-interacting protein; TIN2 interacting protein 1; TPP 1; TPP I; TPPI
Gene Aliases: ACD; PIP1; PTOP; TINT1; TPP1
UniProt ID: (Human) Q96AP0
Entrez Gene ID: (Human) 65057
telomere maintenance
skeletal system development
urogenital system development
intracellular protein transport
telomere maintenance via telomerase
telomere capping
embryonic limb morphogenesis
protection from non-homologous end joining at telomere
telomere assembly
negative regulation of telomere maintenance via telomerase
positive regulation of telomere maintenance via telomerase
segmentation
positive regulation of telomerase activity
positive regulation of single-stranded telomeric DNA binding
protein localization to chromosome, telomeric region
establishment of protein localization to telomere
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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