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Invitrogen

hnRNP U Polyclonal Antibody

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hnRNP U Polyclonal Antibody

Product Details

PA5-63604

Applications
Tested Dilution
Publications

Western Blot (WB)

0.04-0.4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500
-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human hnRNP U. Recombinant protein control fragment (Product #RP-104127).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Amount

10 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2642502

Product Specific Information

Immunogen sequence: AVLKMKGNFT LPEVAECFDE ITYVELQKEE AQKLLEQYKE ESKKALPPEK KQNTGSKKSN KNKSGKNQFN RGGGHRGRGG FNMRGG

Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Target Information

The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: contains signal peptide domain; FLJ30202; FLJ37978; GRIP120; Heterogeneous nuclear ribonucleoprotein U; heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); hnRNP U; HNRNPU antisense RNA 1; NCRNA00201; Nuclear p120 ribonucleoprotein; p120; p120 nuclear protein; pp120; SAF-A; SAR-DNA binding protein of the nuclear scaffold; Scaffold-attachment factor A; U211; unnamed protein product

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Gene Aliases: C1orf199; DEE54; EIEE54; GRIP120; hnRNP U; HNRNPU; HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1

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UniProt ID: (Human) Q00839

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Entrez Gene ID: (Human) 3192

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Function(s)
nucleotide binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core binding TFIIH-class transcription factor binding DNA binding chromatin binding double-stranded DNA binding single-stranded DNA binding transcription corepressor activity RNA binding double-stranded RNA binding single-stranded RNA binding mRNA 3'-UTR binding actin binding protein binding ATP binding poly(A) binding snRNA binding poly(C) RNA binding chromatin DNA binding poly(G) binding piRNA binding pre-mRNA binding identical protein binding ribonucleoprotein complex binding sequence-specific DNA binding macromolecular complex binding telomerase RNA binding RNA polymerase II C-terminal domain binding lncRNA binding sequence-specific double-stranded DNA binding promoter-specific chromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter alternative mRNA splicing, via spliceosome regulation of alternative mRNA splicing, via spliceosome mRNA splicing, via spliceosome osteoblast differentiation chromatin organization RNA processing mRNA processing regulation of mitotic cell cycle RNA splicing dosage compensation by inactivation of X chromosome regulation of gene expression positive regulation of macromolecule biosynthetic process mRNA metabolic process cell differentiation erythrocyte differentiation chromatin silencing by small RNA negative regulation of telomere maintenance via telomerase circadian regulation of gene expression negative regulation of kinase activity negative regulation of transcription elongation from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter mRNA stabilization rhythmic process cell division maintenance of protein location in nucleus cardiac muscle cell development random inactivation of X chromosome CRD-mediated mRNA stabilization cellular response to glucocorticoid stimulus positive regulation of brown fat cell differentiation dendritic transport of messenger ribonucleoprotein complex negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay regulation of mitotic spindle assembly regulation of chromatin organization positive regulation of attachment of mitotic spindle microtubules to kinetochore protein localization to spindle microtubule RNA localization to chromatin cellular response to leukemia inhibitory factor adaptive thermogenesis positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity positive regulation of stem cell proliferation negative regulation of stem cell differentiation positive regulation of cytoplasmic translation
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