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Invitrogen
LRRC4B Polyclonal Antibody
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Product Details
PA5-63638
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human LRRC4B. Recombinant protein control fragment (Product #RP-101924).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GTEKEPPGPT TDGVWGGGRP GDAAGPASSS TTAPAPRSSR PTEKAFTVPI TDVTENALKD LDD
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
Target Information
The LRRC4B gene encodes a protein known as leucine-rich repeat-containing protein 4B, which is involved in cellular signaling and neural development. LRRC4B is a member of the leucine-rich repeat (LRR) protein family, characterized by its ability to mediate protein-protein interactions through its LRR domains. This protein is predominantly expressed in the nervous system and plays a crucial role in neuronal growth, synapse formation, and signal transduction pathways essential for brain development and function. LRRC4B contributes to cell adhesion, growth cone guidance, and synaptic plasticity, influencing the formation and maintenance of neural circuits. Its dysregulation has been linked to neurodevelopmental disorders, highlighting its importance in cognitive functions and neurological health. Additionally, LRRC4B is implicated in cancer biology, where it may act as a tumor suppressor, modulating cellular proliferation and migration. Research continues to explore LRRC4B's interactions and regulatory mechanisms, offering insights into potential therapeutic applications for neurological diseases and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leucine-rich repeat-containing protein 4B; leucine-rich repeats and immunoglobulin-like domains 4; netrin-G ligand-3; Netrin-G3 ligand; NGL-3
Gene Aliases: HSM; LRIG4; LRRC4B; NGL-3
UniProt ID: (Human) Q9NT99
Entrez Gene ID: (Human) 94030
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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